| 產(chǎn)品編號 | bs-19926R-APC |
| 英文名稱1 | Rabbit Anti-SMARCD2/APC Conjugated antibody |
| 中文名稱 | APC標(biāo)記的SWI/SNF相關(guān)基質(zhì)關(guān)聯(lián)肌動(dòng)蛋白依賴染色質(zhì)調(diào)控因子亞家族D2抗體 |
| 別 名 | 60 kDa BRG 1/Brm associated factor subunit B; 60 kDa BRG1/Brm associated factor subunit B; BAF60B; BRG1 associated factor 60B; Chromatin remodeling complex BAF60B subunit; CRACD 2; CRACD2; Mammalian chromatin remodeling complex BRG1 associated factor 60B; PRO2451; Rsc6p; SMARCD 2; SWI/SNF complex 60 kDa subunit B; SWI/SNF related matrix associated actin dependent regulator of chromatin d2; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily d member 2; Swp73 like protein. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 染色質(zhì)和核信號 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 52kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SMARCD2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Subunit: Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. May interact with SMARCA4, the catalytic subunit of the SWI/SNF related nucleosome-remodeling complexes BRG1(I) and BRG1(II). The precise distribution of the related SMARCD1, SMARCD2 and SMARCD3 proteins among these and other SWI/SNF nucleosome-remodeling complexes is not fully known. Interacts with UNKL. Subcellular Location: Nuclear Tissue Specificity: Isoform 2 is expressed in the pancreas. Post-translational modifications: Ubiquitinated through a signaling process involving RAC1 and the RING finger protein UNKL. Similarity: Belongs to the SMARCD family. Contains 1 SWIB domain. Database links: Entrez Gene: 6603 Human Entrez Gene: 83796 Mouse Omim: 601736 Human SwissProt: Q92925 Human SwissProt: Q99JR8 Mouse Unigene: 250581 Human Unigene: 21772 Mouse Unigene: 3053 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
