| 產(chǎn)品編號(hào) | bs-4269R-BF488 |
| 英文名稱1 | Rabbit Anti-CDKN2B/p15 INK4b/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的細(xì)胞周期蛋白依賴性激酶抑制劑2B抗體 |
| 別 名 | CDK inhibitory protein; CDK4B Inhibitor; CDKN2B; Cyclin dependent kinase 4 inhibitor B; Cyclin Dependent Kinase Inhibitor 2B; Cyclin dependent kinase inhibitor 2B p15 inhibits CDK4; Cyclin-dependent kinases 4 and 6 binding protein; INK4B; MTS 2; MTS2; Multiple Tumor Supressor 2; p14 CDK inhibitor; p14 INK4b; P15; p15 CDK inhibitor; p15 inhibits CDK4; p15 INK4b; P15(INK4B); p15INK4B; TP 15; TP15. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 干細(xì)胞 細(xì)胞周期蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Rat, (predicted: Human, Mouse, Chicken, Dog, Cow, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 15kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CDKN2B |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: p15 INK4b / MTS 2 (Mitotic Inhibitor / Suppressor Protein) is a specific inhibitor of cdk 4 / cdk 6 and is periodically expressed during the cell cycle. Reportedly, p15 INK4b expression is induced approximately 30 fold in human keratinocytes by treatment with TGF beta, suggesting that p15 INK4b may act as an effector of TGF beta mediated cell cycle arrest. p15 INK4b is mapped to chromosome 9p21, a region of frequent loss in a wide variety of cancers. Function: Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest. Subunit: Heterodimer of CDKN2B with CDK4 or CDK6. Isoform 2 does not interact with CDK4 nor CDK6. Subcellular Location: Cytoplasm. Note=Also found in the nucleus. Tissue Specificity: Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines. Similarity: Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. Contains 4 ANK repeats. Database links: Entrez Gene: 1030 Human Entrez Gene: 12579 Mouse Omim: 600431 Human SwissProt: P42772 Human SwissProt: P55271 Mouse Unigene: 72901 Human Unigene: 423094 Mouse Unigene: 105626 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
