| 產(chǎn)品編號 | bs-0272R-BF488 |
| 英文名稱1 | Rabbit Anti-Visfatin/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的內(nèi)脂素/內(nèi)臟脂肪素/前B細(xì)胞克隆增強因子1抗體 |
| 別 名 | pre-B-cell colony-enhancing factor 1; PBEF1 protein; AI480535; 1110035O14Rik; AI314458; DKFZP666B131; EC 2.4.2.12; MGC117256; NAmPRTase; NAMPT; Nicotinamide phosphoribosyltransferase; PBEF; PBEF1; Pre B cell colony enhancing factor 1; Pre B cell colony enhancing factor; Pre B cell enhancing factor; Visfatin; NAMPT_HUMAN. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 心血管 神經(jīng)生物學(xué) 糖尿病 內(nèi)分泌病 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, Rat, (predicted: Chicken, Pig, Cow, Horse, Monkey, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 55kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PBEF |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011]. Function: Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. Subunit: Homodimer. Subcellular Location: Cytoplasm. Tissue Specificity: Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues. Similarity: Belongs to the NAPRTase family. Database links: Entrez Gene: 10135 Human Entrez Gene: 59027 Mouse Omim: 608764 Human SwissProt: P43490 Human SwissProt: Q99KQ4 Mouse Unigene: 489615 Human Unigene: 202727 Mouse Unigene: 203508 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 一種新的脂肪因子-visfatin是新近發(fā)現(xiàn)的主要由人和小鼠內(nèi)臟脂肪組織分泌的一種脂肪細(xì)胞因子,其結(jié)構(gòu)與pre-B細(xì)胞集落增強因子相似.它能夠發(fā)揮類似胰島素的作用,與Ⅱ型糖尿病相關(guān)聯(lián),降低血糖,促進糖攝取,可結(jié)合并活化胰島素受體,激活胰島素信號通路.內(nèi)臟脂肪因子-Visfatin與肥胖密切相關(guān)并能夠促進脂肪細(xì)胞的分化,還能促進血管平滑肌細(xì)胞成熟. Visfatin的表達(dá)受炎癥反應(yīng)因子和多種激素的調(diào)節(jié).PBEF-1可能是聯(lián)系機體糖脂代謝的重要分子,它的發(fā)現(xiàn)可為揭示糖尿病與肥胖的發(fā)生發(fā)展機制提供新的研究思路,為代謝綜合征的治療提供新方案. |
