| 產(chǎn)品編號 | bs-1042R-AP |
| 英文名稱1 | Rabbit Anti-MCSF/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的巨噬細胞克隆刺激因子抗體 |
| 別 名 | M-CSF; Macrophage Colony Stimulating Factors; Colony stimulating factor 1 (macrophage); Colony stimulating factor 1; Colony stimulating factor macrophage specific; CSF 1; CSF1; Csfm; Lanimostim; M CSF; Macrophage Colony Stimulating Factor 1; MCSF; MGC31930. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細胞生物 免疫學(xué) 發(fā)育生物學(xué) 信號轉(zhuǎn)導(dǎo) 激酶和磷酸酶 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 60kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse MCSF |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Four distinct colony-stimulating factors (CSFs) that promote survival, proliferation and differentiation of bone marrow precursor cells have been well characterized: granulocyte macrophage CSF (GMCSF), granulocyte CSF (GCSF), macrophage CSF (MCSF), and Interleukin-3 (IL-3, Multi CSF). Both GMCSF and IL-3 are multipotential growth factors, stimulating proliferation of progenitor cells from more than one hematopoietic lineage. In contrast, GCSF and MCSF are lineage restricted hematopoietic growth factors, stimulating final mitotic divisions and the terminal cellular maturation of the partially differentiated hematopoietic progenitors. Macrophage CSF, also known as CSF1, is produced by monocytes, fibroblasts and endothelial cells. It stimulates the formation of macrophage colonies, enhances antibody-dependent, cell-mediated cytotoxicity by monocytes and macrophages, and inhibits bone resorption by osetoclasts. Natural human MCSF is a dimeric glycoprotein of 70-90 kD molecular weight, existing in multiple glycosylation forms. It binds to a 165 kD glycoprotein of the receptor tyrosine kinase subclass III, a family that includes the receptors for platelet derived growth factor (PDGF) and stem cell factor (SCF). Function: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. Subunit: Homodimer or heterodimer; disulfide-linked. Interacts with CSF1R. Subcellular Location: Cell membrane; Single-pass membrane protein. Processed macrophage colony-stimulating factor 1: Secreted, extracellular space. Post-translational modifications: N-glycosylated. The predominant soluble form is a chondroitin sulfate-containing proteoglycan. DISEASE: Note=A defect in Csf1 is the cause of osteopetrosis. Osteopetrotic mice (op/op) are severely deficient in mature macrophages and osteoclasts, display failed tooth eruption, and have a restricted capacity for bone remodeling. Database links: Entrez Gene: 1435 Human Entrez Gene: 12977 Mouse Omim: 120420 Human SwissProt: P09603 Human SwissProt: P07141 Mouse Unigene: 591402 Human Unigene: 795 Mouse Unigene: 83632 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. M-CSF是促使造血細胞分化成粒細胞與巨噬細胞克隆的重要細胞因子,對正常血細胞的形成與造血細胞 的存活、分化、正常造血功能 的維持具有重要作用,直接與間接增加lak細胞的活性,在人體 的細胞因子網(wǎng)絡(luò)中占有重要 的地位,目前廣泛應(yīng)用于化.放療 的輔助治療中。 目前研究主要應(yīng)用在免疫缺陷性疾病及病毒性疾病：慢性肝病,尤其是與病毒相關(guān)的疾病,因其發(fā)病過程涉及免疫細胞與造血系統(tǒng),有可能成為gm-csf(粒細胞-巨噬細胞克隆刺激因子)應(yīng)用的新領(lǐng)域。人和小鼠天然M-CSF為糖蛋白，由二硫鍵連接的同源雙體，分子量40～90kDa。人和小鼠M-CSF分子這個區(qū)域結(jié)構(gòu)高度保守，其同源性達80％。 |
