| 產(chǎn)品編號 | bs-0749R-AP |
| 英文名稱1 | Rabbit Anti-Kisspeptin/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的腫瘤轉(zhuǎn)移抑制基因抗體 |
| 別 名 | AXOR 12; AXOR12; G protein coupled receptor 54; GPCR 54; GPCR54; GPR 54; GPR54; HOT7T175; Hypogonadotropin 1; Hypogonadotropin1; KISS 1 receptor; KISS 1R; KISS1 receptor; KISS1R; Kisspeptins receptor; metastin receptor; KISS 1; KiSS 1 metastasis suppressor; KISS-1; KISS1_HUMAN; Kisspeptin 1; Kisspeptin 10; Kisspeptin 13; Kisspeptin 14; Kisspeptin; Kisspeptin-1; Kisspeptin-10; Kisspeptin-54; Kisspeptin1; Malignant melanoma metastasis suppressor; Metastasis suppressor KiSS 1; Metastasis suppressor KiSS1; Metastin; MGC39258. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, Rat, (predicted: Cow, Sheep, ) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 16kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Kiss-1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq, Mar 2012] Function: Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Subcellular Location: Secreted. Tissue Specificity: Very high expression in placenta, with the next highest level in testis and moderate levels in pancreas, liver, small intestine and brain at much lower levels. Expression levels increased in both early placentas and molar pregnancies and are reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation, but only expressed in the villous trophoblast. Post-translational modifications: Processed by MMP2 and MMP9. Similarity: Belongs to the KISS1 family. Database links: Entrez Gene: 3814 Human Omim: 603286 Human SwissProt: Q15726 Human Unigene: 95008 Human Unigene: 66008 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Kiss-1主要用于腫瘤及腫瘤轉(zhuǎn)移方面的研究。近年來Kiss-1與MMP-9、MMP-2 是腫瘤轉(zhuǎn)移、浸潤研究的熱門課題。 |
