| 產(chǎn)品編號(hào) | bs-0529R-AP |
| 英文名稱 | Rabbit Anti-IL-18/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的白細(xì)胞介素-18/干擾素γ誘導(dǎo)因子抗體 |
| 別 名 | interferon gamma-inducing factor IGIF; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; Iboctadekin; IFN gamma inducing factor; IGIF; IL 1 gamma; IL 18; IL 1g; IL1 gamma; IL18 protein; IL1F4; IL1g; IL1gamma; ILIF4; Interferon gamma inducing factor; Interleukin 1 gamma; Interleukin 18; Interleukin18; MGC12320; IL18_MOUSE. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書 | 100ul |
| 研究領(lǐng)域 | 免疫學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, Rat, |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 17kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse IL-18 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: IL18 (IFN-gamma-inducing factor, IGIF) is a novel pro-inflammatory cytokine that augments natural killer (NK) activity in spleen cells. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. IL18 also has other biological properties such as stimulation of Fas ligand expression, and induction of CC and CXC chemokines. IL18 increases production of competent HIV. IL18 is related to the IL1 family. One of the IL18 receptor chains is the IL1 receptor-related protein, a member of the IL 1R family. Like IL1 , IL18 is first synthesized as a leaderless precursor requiring the IL1 converting enzyme (ICE) for cleavage into an active molecule. IL18 may play a role in tissue injury in inflammatory reactions. Function: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. Subcellular Location: Secreted. Similarity: Belongs to the IL-1 family. Database links:
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. IL-18是巨噬細(xì)胞分泌的一個(gè)重要因子，它具有多種免疫功能，能誘導(dǎo)產(chǎn)生ＩＦＮγ，無(wú)論在病毒感染早期或特異性細(xì)胞免疫應(yīng)答效應(yīng)階段都會(huì)出現(xiàn)，因此IL-18主要參與免疫應(yīng)答及炎性細(xì)胞浸潤(rùn)的改變。Interleukin-18 又稱inteferon-gamma inducing factor(IGIF)，在輔助T細(xì)胞的應(yīng)答反應(yīng)中起重要作用。IL-18和IL-1一起，既參與先天免疫，又是后天免疫的構(gòu)成因素。 |
