| 產(chǎn)品編號 | bs-1104R-BF488 |
| 英文名稱1 | Rabbit Anti-TBX2/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的新型抑癌基因抗體 |
| 別 名 | T-bet; T-box2; T-box Protein 2; T-box transcription factor TBX2; T-box protein 2; FLJ10169; HGNC: 11597; T box 2; T box transcription factor TBX2; TBX2; TBX2_HUMAN. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Rat, (predicted: Human, Mouse, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 74kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TBX2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. Function: Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. Subunit: Interacts with PML (isoform-PML-2, isoform PML-3 and isoform PML-4). Subcellular Location: Nucleus. Tissue Specificity: Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary. Similarity: Contains 1 T-box DNA-binding domain. Database links: Entrez Gene: 6909 Human Entrez Gene: 21385 Mouse Omim: 600747 Human SwissProt: Q13207 Human SwissProt: Q60707 Mouse Unigene: 531085 Human Unigene: 287052 Mouse
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 經(jīng)研究發(fā)現(xiàn)，在人黑色素瘤及很多惡性腫瘤組織中普遍存在TBX2基因表達(dá)的增高,該蛋白與惡性腫瘤的發(fā)生、發(fā)展密切相關(guān).TBX2基因被認(rèn)為是一種新發(fā)現(xiàn)的抑癌基因。 |
