| 產(chǎn)品編號(hào) | bs-1846R-BF488 |
| 英文名稱1 | Rabbit Anti-LRIG3/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的LRIG3抗體 |
| 別 名 | leucine rich repeats and immunoglobulin-like domains 3; LIG3; LRIG1-3; LRIG3_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 121kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LRIG3 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: LRIG3 is predicted to be a 1117 amino acid single pass transmembrane protein with 15 leucine rich repeats and 3 Ig domains in the extracellular region, and a short, novel cytoplasmic tail with no known motifs. It is believed that LRIG3 influences lateral ear canal morphogenesis. Expression and sub-cellular localization of LRIG3 might be of importance in the pathogenesis and prognosis of astrocytic tumors. Function: May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity). Subunit: Interacts with EGFR, ERBB2 and ERBB4 (in vitro) (By similarity). Subcellular Location: Cell membrane; Single-pass type I membrane protein (By similarity). Cytoplasmic vesicle membrane; Single-pass type I membrane protein (By similarity). Note=Detected in cytoplasmic vesicles when coexpressed with ERBB4 (By similarity). Tissue Specificity: Widely expressed. Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 15 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. Database links: Entrez Gene: 121227 Human SwissProt: Q6UXM1 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. LRIG1屬于LRIGs基因家族。LRIGs是新發(fā)現(xiàn)的一類基因，在哺乳動(dòng)物體內(nèi)廣泛存在，目前發(fā)現(xiàn)該家族至少包括三個(gè)成員：LRIG1、LRIG2和LRIG3，是一類結(jié)構(gòu)相似的跨膜糖蛋白，該蛋白人、鼠的同源性較高。目前在腫瘤方面的研究較多，有研究認(rèn)為：LRIG1是通過下調(diào)EGFR的表達(dá)來抑制其下游重要信號(hào)傳導(dǎo)通路的激活而發(fā)揮抑癌作用，LRIG1在抑制腫瘤轉(zhuǎn)移中具有重要作用。 |
