| 產(chǎn)品編號(hào) | bs-1574R-BF488 |
| 英文名稱1 | Rabbit Anti-RRM1/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的核糖核苷酸還原酶1抗體 |
| 別 名 | ribonucleotide reductase R1 mRNA; R1; Ribonucleoside diphosphate reductase large subunit ; Ribonucleoside diphosphate reductase M1 chain; Ribonucleoside diphosphate reductase subunit M1; Ribonucleotide reductase large chain; Ribonucleotide reductase large subunit; Ribonucleotide reductase M1 polypeptide; Ribonucleotide reductase R1 subunit; RIR 1; RIR1; RR 1; RR1; RRM 1; RIR1_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 染色質(zhì)和核信號(hào) 激酶和磷酸酶 細(xì)胞分化 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 90kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RRM1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: RRM1 (Ribonucleotide reductase M1 polypeptide) is one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme which catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RRM1 is involved in carcinogenesis, tumor progression, and the response of non-small-cell lung cancer to treatment. Function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Subunit: Heterodimer of a large and a small subunit. Heterodimer with small subunit RRM2 or RRM2B. The heterodimer with RRM2 has higher catalytic activity than the heterodimer with RRM2B. Subcellular Location: Cytoplasm. Similarity: Belongs to the ribonucleoside diphosphate reductase large chain family. Contains 1 ATP-cone domain. Database links: Entrez Gene: 6240 Human Entrez Gene: 20133 Mouse Omim: 180410 Human SwissProt: P23921 Human SwissProt: P07742 Mouse Unigene: 445705 Human Unigene: 197486 Mouse Unigene: 162454 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 核糖核苷酸還原酶普遍存在于很多生物中,是生物體內(nèi)唯一的催化4種核糖核苷酸還原并生成相應(yīng)的脫氧核糖核苷酸的酶. 核糖核苷酸還原酶1也是DNA合成和修復(fù)的關(guān)鍵酶和限速酶,對(duì)細(xì)胞的增殖和分化起著調(diào)控作用。 |
