| 產(chǎn)品編號 | bs-6250R-BF488 |
| 英文名稱1 | Rabbit Anti-DPPL1/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的磷脂酸磷酸酶HTPAP抗體 |
| 別 名 | diacylglycerol pyrophosphate like 1; DPPL1; EC=3.1.3.4; HTPAP; Phosphatidate phosphatase PPAPDC1B; Phosphatidic acid phosphatase type 2 domain-containing protein 1B; PPAPDC1B; PPC1B_HUMAN. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 信號轉(zhuǎn)導(dǎo) 激酶和磷酸酶 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 29kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DPPL1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: DPPL1 and is a 223 amino acid protein that is localized to the cellular membrane. HTPAP is a multi-pass membrane protein which is thought to possess six transmembrane spanning domains and is expressed as two isoforms. HTPAP is a member of the PAP related phosphoesterase family and the gene encoding HTPAP is highly conserved among many species. HTPAP functions as a PAP for lipid phosphate substrates, including PA (phosphatidate), LPA (lysophatidate) and DGPP (diacylglycerol pyrophosphate), but preferentially targets DGPP. Breast cancer tumors, specifically those in which ER (estrogen receptor) is present in high amounts, exhibit upregulation of the gene which encodes HTPAP and HTPAP is thought to increase ER activity. Due to the overexpression of HTPAP in ductal breast carcinomas and the observation that, in cases of lower HTPAP expression, tumors grew slower, HTPAP is thought to be an oncogene. In contrast, the gene encoding HTPAP is downregulated in HCC (hepatocellular carcinoma) and is thought to inhibit lung metastasis. Function: Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma. Subcellular Location: Membrane; Multi-pass membrane protein Tissue Specificity: Ubiquitous. Similarity: Belongs to the PA-phosphatase related phosphoesterase family. Database links: Entrez Gene: 84513 Human Entrez Gene: 71910 Mouse Omim: 610626 Human SwissProt: Q8NEB5 Human SwissProt: Q3UMZ3 Mouse Unigene: 567619 Human Unigene: 385055 Mouse Unigene: 199008 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
