| 產(chǎn)品編號 | IHC0507H |
| 英文名稱 | Human HSF1 Ready-To-Use IHC Kit |
| 中文名稱 | 人熱休克因子1即用型免疫組化試劑盒 |
| 別 名 | Heat shock factor 1; Heat shock factor protein 1; Heat shock transcription factor 1; HSF 1; hsf1; HSF1_HUMAN; HSTF 1; HSF1; HSTF1 |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
All organisms respond to elevated temperatures and a variety of environmental stresses by rapid synthesis of heat shock RNAs and proteins. The regulation of heat shock gene transcription is mediated by the transcriptional activator, heat shock factor (HSF), which binds to heat shock response elements (HSEs). These HSEs are found as three repeats of a 5-nucleotide {nGAAn} module, arranged in alternating orientation and present upstream of all heat shock genes. The HSEs are highly conserved among species yet HSF purified from yeast, Drosophila and human have different molecular weights and the proteins do not show significant immunological cross reaction. Two HSFs have been identified in human cells, HSF1 and HSF2, which bind to the same HSEs and have 38% sequence identity. These factors are activated by distinct stimuli, HSF1 is responsive to classical stress signals such as heat, heavy metals and oxidative reagents, whereas HSF2 is activated during hemin-mediated differentiation of human erythroleukemia cells. HSF1 exists constitutively in the cytoplasm and the nucleus of unstressed cells as a monomer which lacks DNA binding activity. Through an unknown signal generated during stress, HSF1 becomes activated to a nuclear localized, trimeric state which binds to DNA. The phosphorylation of HSF1 is necessary for maximal transcription of heat shock genes. SWISS: Q00613 Gene ID: 3297 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded Human breast cancer tissue slide using IHC0507H (Human HSF1 Kit).
Immunohistochemical analysis of paraffin embedded Human ovarian cancer tissue slide using IHC0507H (Human HSF1 Kit).
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Immunohistochemical analysis of paraffin embedded Human colon cancer tissue slide using IHC0507H (Human HSF1 Kit).
Immunohistochemical analysis of paraffin embedded Human testis tissue slide using IHC0507H (Human HSF1 Kit).
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