| 產(chǎn)品編號(hào) | D51473 |
| 英文名稱(chēng) | PRI-724 |
| 中文名稱(chēng) | |
| 別 名 | β-catenin/CBP抑制劑 |
| 克 隆 號(hào) | |
| CAS | 1422253-38-0 |
| 理論分子量 | 658.64 kDa |
| 檢測(cè)分子量 | |
| 性 狀 | Lyophilized |
| 保存條件 | Store in dry, dark place for one year. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
PRI-724, also known as C-82 prodrug/ICG-001 analog, is a potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity. Wnt signaling pathway inhibitor PRI-724 specifically inhibits the recruiting of beta-catenin with its coactivator CBP (the binding protein of the cAMP response element-binding protein CREB); together with other transcription factors beta-catenin/CBP binds to WRE (Wnt-responsive element) and activates transcription of a wide range of target genes of Wnt/beta-catenin signaling. Note: Chemical structures of ICG-001 and PRR-724 look very close, but they are not the same molecule. Many vendors confused them. |
