| 產(chǎn)品編號(hào) | D51288 |
| 英文名稱 | LY-303511 |
| 中文名稱 | |
| 別 名 | mTOR抑制劑 |
| 克 隆 號(hào) | |
| CAS | 154447-38-8 |
| 理論分子量 | 306.36 kDa |
| 檢測分子量 | |
| 性 狀 | Lyophilized |
| 保存條件 | Store in dry, dark place for one year. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
LY-303511, also known as NV-128 and EM 101, is a potent mTOR inhibitor. LY-303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. LY-303511 amplifies TRAIL-induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization. LY-303511 acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms. |
