| 產(chǎn)品編號(hào) | D51250 |
| 英文名稱 | GW806742X |
| 中文名稱 | |
| 別 名 | MLKL抑制劑 |
| 克 隆 號(hào) | |
| CAS | 579515-63-2 |
| 理論分子量 | 573.55 kDa |
| 檢測(cè)分子量 | |
| 性 狀 | Lyophilized |
| 保存條件 | Store in dry, dark place for one year. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
GW806742X is a potent MLKL inhibitor, also a human and murine necroptosis inhibitor. GW806742X binds the MLKL pseudokinase domain with a Kd value of 9.3 μM and has anti-necroptosis activity. GW806742X has activity against VEGFR2. GW806742X blocked necroptosis and IL-33 release in vitro and reduced eosinophilia in Aspergillus fumigatus extract-induced asthma in vivo, an allergic inflammation model that is highly dependent on IL-33. |
