| 產(chǎn)品編號 | D51232 |
| 英文名稱 | KPT-330 |
| 中文名稱 | |
| 別 名 | CRM1抑制劑 |
| 克 隆 號 | |
| CAS | 1393477-72-9 |
| 理論分子量 | 443.31 kDa |
| 檢測分子量 | |
| 性 狀 | Lyophilized |
| 保存條件 | Store in dry, dark place for one year. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
KPT-330 is an orally bioavailable, potent and selective XPO1/CRM1 Inhibitor. KPT-330 is effective in acquired resistance to ibrutinib and synergizes with ibrutinib in chronic lymphocytic leukemia. KPT-330 potentiates the antitumor activity of gemcitabine in human pancreatic cancer through inhibition of tumor growth, depletion of the antiapoptotic proteins, and induction of apoptosis. KPT-330 has strong activity against primary AML cells while sparing normal stem and progenitor cells. |
