| 產(chǎn)品編號(hào) | D51192 |
| 英文名稱 | Ruxolitinib |
| 中文名稱 | |
| 別 名 | JAK1/2抑制劑 |
| 克 隆 號(hào) | |
| CAS | 941678-49-5 |
| 理論分子量 | 306.37 kDa |
| 檢測分子量 | |
| 性 狀 | Lyophilized |
| 保存條件 | Store in dry, dark place for one year. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
Ruxolitinib, also known as INC424 and INCB18424 or INCB018424, is an orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Ruxolitinib specifically binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies. CAS號(hào)：941678-49-5 分子式：C17H18N6 分子量：306.37 MDL：MFCD12031592 純度：≥98% (HPLC) 作用靶點(diǎn)：JAK; Autophagy; Mitophagy; Apoptosis; 作用通路：Epigenetics; JAK/STAT Signaling; Stem Cell/Wnt; Autophagy; Apoptosis; 介紹：魯索利替尼 (Ruxolitinib, INCB18424) 是有效的，選擇性的 JAK1/2 抑制劑， IC50 值 |
