| 產(chǎn)品編號 | D51186 |
| 英文名稱 | Varenicline |
| 中文名稱 | |
| 別 名 | α4β2 nAChR/α7 nAChR/α3β4 nAChR激動劑 |
| 克 隆 號 | |
| CAS | 249296-44-4 |
| 理論分子量 | 211.26 kDa |
| 檢測分子量 | |
| 性 狀 | Lyophilized |
| 保存條件 | Store in dry, dark place for one year. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
Varenicline is a nicotinic receptor partial agonist—it stimulates nicotine receptors more weakly than nicotine itself does. In this respect it is similar to cytisine and different from the nicotinic antagonist, bupropion, and nicotine replacement therapies (NRTs) like nicotine patches and nicotine gum. Varenicline displays full agonism on α7 nicotinic acetylcholine receptors and is a partial agonist on the α4β2, α3β4, and α6β2 subtypes. In addition, it is a weak agonist on the α3β2 containing receptors. Varenicline's partial agonism on the α4β2 receptors rather than nicotine's full agonism produces less effect of dopamine release than nicotine's. This α4β2 competitive binding reduces the ability of nicotine to bind and stimulate the mesolimbic dopamine system—similar to the method of action of buprenorphine in the treatment of opioid addiction. CAS：249296-44-4 分子式：C13H13N3 分子量：211.26 MDL：MFCD10001497 純度：≥99.5% (HPLC) 作用靶點：nAChR; 作用通路：Membrane Transporter/Ion Channel; Neuronal Signaling； 產(chǎn)品描述：伐倫克林 (Varenicline) 是 α4β2 nAChR 煙堿乙酰膽堿受體的一個部分激動劑 (EC50=2.3 μM)。Varenicline 是 α3β4 nAChR 和 α7 nAChR 乙酰膽堿受 |
