| 產(chǎn)品編號 | D51165 |
| 英文名稱 | GSK-2606414 |
| 中文名稱 | |
| 別 名 | PERK抑制劑 |
| 克 隆 號 | |
| CAS | 1337531-36-8 |
| 理論分子量 | 451.44 kDa |
| 檢測分子量 | |
| 性 狀 | Lyophilized |
| 保存條件 | Store in dry, dark place for one year. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
GSK-2606414 is an orally available, potent, and selective PERK inhibitor. GSK-2606414 inhibits PERK activation in cells and inhibits the growth of a human tumor xenograft in mice. Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states. Evidence that PERK is implicated in tumorigenesis and cancer cell survival stimulated our search for small molecule inhibitors. |
