| 產(chǎn)品編號(hào) | BSKH64147 |
| 英文名稱(chēng) | Human Protein Tyrosine Phosphatase, Non Receptor Type 1 (PTPN1) ELISA Kit |
| 中文名稱(chēng) | 人非受體型蛋白酪氨酸磷酸酶1(PTPN1) ELISA Kit |
| 別 名 | PTP1B; PTP1-B; Protein-tyrosine phosphatase 1B |
| 克 隆 號(hào) | |
| 適用樣品基質(zhì) | tissue homogenates or other biological fluids. |
| 保存條件 | Srore at 4℃ & -20℃ for 12 months. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
The kit is a sandwich enzyme immunoassay for the in vitro quantitative measurement of PTPN1 in human tissue homogenates or other biological fluids. 蛋白酪氨酸磷酸酶1B（PTP1B）是一種胰島素信號(hào)的負(fù)性調(diào)節(jié)因子，與肥胖癥和2型糖尿病的發(fā)病及發(fā)展關(guān)系密切。對(duì)P-tyr基因敲除小鼠的研究表明，缺失PTP1B小鼠的胰島素敏感性明顯增加，并對(duì)肥胖有一定的抵抗作用，而另一些對(duì)動(dòng)物和人體的研究結(jié)果卻與此相反，發(fā)現(xiàn)PTP1B可通過(guò)引起胰島素抵抗、瘦素抵抗及影響脂代謝等而導(dǎo)致肥胖癥和2型糖尿病的發(fā)生。一些特異性的Ptyr小分子抑制劑已經(jīng)開(kāi)發(fā)并用于肥胖和糖尿病的治療中。 |
