| 產(chǎn)品編號 | bs-11606R |
| 英文名稱 | Rabbit Anti-TWSG1 antibody |
| 中文名稱 | 扭轉(zhuǎn)原腸胚形成同源蛋白1抗體 |
| 別 名 | PSEC0250; TSG; TSG1; twisted gastrulation homolog 1; Twisted gastrulation protein; TWSG1_HUMAN. |
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Specific References (1) | bs-11606R has been referenced in 1 publications.
[IF=1.394] Liu Zhuohang. et al. Twisted gastrulation signaling modulator 1 promotes the ability of glioma cell through activating Akt pathway. Neuroreport. 2021 Feb;32(3):198-205 IHC ; Human.
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| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 22kDa |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TWSG1: 151-223/223 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Twisted Gastrulation Protein 1(TWSG1) is a secreted BMP binding protein structurally related to the BMP antagonists Chordin and Noggin. TSG can inhibit BMP activity by binding directly to BMP proteins thereby preventing BMPs from binding to their receptors. It can act either as a BMP4 agonist or antagonist (depending on the specific biochemical environment) by binding to the BMP4/Chordin complex. Function: May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development Subunit: nteracts with CHRD and BMP4. This interaction enhances CHRD/BMP4 complex formation. Interacts with BMP7 Subcellular Location: Secreted Similarity: Belongs to the twisted gastrulation protein family. SWISS: Q9GZX9 Gene ID: 57045 Database links: Entrez Gene: 57045 Human Entrez Gene: 705804 Rhesus monkey Omim: 605049 Human SwissProt: Q9GZX9 Human Unigene: 514685 Human
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