| 產品編號 | bs-5077R |
| 英文名稱 | Ceramide synthase 2 Rabbit pAb |
| 中文名稱 | 腫瘤轉移抑制基因1抗體 |
| 別 名 | LASS2; TMSG-1; CerS 2; CerS2; L3 antibody LAG1 homolog ceramide synthase 2; LAG1 longevity assurance 2; LAG1 longevity assurance homolog 2; LASS 2; Longevity assurance(LAG1 S. cerevisiae) homolog 2; TMSG 1; TMSG1; Tumor metastasis suppressor; Tumor metastasis suppressor gene 1 protein; FLJ10243; MGC987; SP 260; SP260. |
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Specific References (1) | bs-5077R has been referenced in 1 publications.
[IF=2.98] Chen et al. Enhancement of DEN-induced liver tumourigenesis in hepatocyte-specific Lass2-knockout mice coincident with upregulation of the TGF-β1-Smad4-PAI-1 axis. (2014) Oncol.Rep. 31:885-93 WB ; Mouse.
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| 研究領域 | 腫瘤 免疫學 信號轉導 轉錄調節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應 | Rat (predicted: Human,Mouse,Rabbit,Pig,Cow,Chicken,Horse) |
| 產品應用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 45 kDa |
| 檢測分子量 | |
| 細胞定位 | 細胞核 細胞漿 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LASS2: 201-300/380 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產品介紹 |
LASS2 (LAG1 homolog, ceramide synthase 2) has sequence similarity to yeast longevity assurance gene 1. It is thought to be involved in sphingolipid synthesis. Expression of LASS2 is transiently increased during the period of active myelination and is specifically localized to white matter tracts of the brain, including the Schwann cells of sciatic nerves suggesting that LASS2 is important for the synthesis of dihydroceramide used for synthesis of myelin sphingolipids. Expression of LASS2 in hepatocellular carcinoma cell lines suppresses the growth of cancer cells. Function: Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis. Subcellular Location: Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Tissue Specificity: Expressed in kidney, liver, brain, heart, placenta and lung Similarity: Contains 1 homeobox DNA-binding domain. Contains 1 TLC (TRAM/LAG1/CLN8) domain. SWISS: Q96G23 Gene ID: 29956 Database links: Entrez Gene: 29956 Human Entrez Gene: 76893 Mouse Omim: 606920 Human SwissProt: Q96G23 Human SwissProt: Q924Z4 Mouse Unigene: 713103 Human Unigene: 741232 Human Unigene: 181009 Mouse |
| 1、抗體溶解方法 | |
| 2、抗體修復方式 | |
| 3、常用試劑的配制 | |
| 4、免疫組化操作步驟 | |
| 5、免疫組化問題解答 | |
| 6、Western Blotting 操作步驟 | |
| 7、Western Blotting 問題解答 | |
| 8、關于肽鏈的設計 | |
| 9、多肽的溶解與保存 | |
| 10、酶標抗體效價測定程序 | |
