| 產(chǎn)品編號 | bs-3855R |
| 英文名稱 | Rabbit Anti-HSD17B1 antibody |
| 中文名稱 | 羥類固醇脫氫酶17β-HSD抗體 |
| 別 名 | 11beta-HSD1; 17beta-HSD1; 17 beta HSD 1; 17 beta hydroxysteroid dehydrogenase type 1; 17β-hydroxysteroid dehydrogenasetype 1 EDH17B2; EDHB17; Estradiol 17 beta dehydrogenase 1; HSD17; Hydroxysteroid (17 beta) dehydrogenase 1; Placental 17 beta hydroxysteroid dehydrogenase; DHB1_HUMAN. |
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Specific References (1) | bs-3855R has been referenced in 1 publications.
[IF=4.2] Zhang, Weidong, et al. "Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable." Chemosphere (2017). IHC-P ; Mouse.
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| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 生長因子和激素 激酶和磷酸酶 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Rabbit,Pig,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 35kDa |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HSD17B1: 21-120/328 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016] Subunit: Homodimer. Subcellular Location: Cytoplasm. Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. SWISS: P14061 Gene ID: 3292 Database links: Entrez Gene: 3292 Human Omim: 109684 Human SwissProt: P14061 Human Unigene: 654385 Human Unigene: 655222 Human Ⅰ型17β-羥類固醇脫氫酶又稱Ⅰ型17HSD，催化雌酮與雌二醇之間的轉(zhuǎn)化，為性激素合成過程中最后步驟的催化酶。它催化性激素Ｃ17位上的酮基和醇基之間的還原和氧化反應(yīng) ,使低生物活性的雌酮、雄烯二酮與高生物活性的雌二醇、睪酮之間相互轉(zhuǎn)化。17βHSD的結(jié)構(gòu)和功能的異常與一些疾病 ,如腫瘤、假兩性等的發(fā)生有密切關(guān)系. |
| 產(chǎn)品圖片 |
Sample:
MOLT-4(Human) Cell Lysate at 30 ug
Primary: Anti- HSD17B1 (bs-3855R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 35 kD
Observed band size: 35 kD
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