| 產(chǎn)品編號 | bs-2265R |
| 英文名稱 | Rabbit Anti-PYY antibody |
| 中文名稱 | 酪酪肽抗體 |
| 別 名 | PYY_HUMAN; Peptide YY; PYY-I; Peptide tyrosine tyrosine; Peptide YY(3-36); PYY-II; PYY1; |
 |
Specific References (1) | bs-2265R has been referenced in 1 publications.
[IF=4.546] Quancheng Liu. et al. FumDSB Can Reduce the Toxic Effects of Fumonisin B1 by Regulating Several Brain-Gut Peptides in Both the Hypothalamus and Jejunum of Growing Pigs. Toxins. 2021 Dec;13(12):874 WB,IHC ; Pig.
|
| 研究領(lǐng)域 | 心血管 免疫學(xué) 神經(jīng)生物學(xué) 生長因子和激素 糖尿病 內(nèi)分泌病 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 4.4kDa |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide human Peptide YY: 29-64/97 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Peptide tyrosine tyrosine (PYY) was originally isolated from porcine gut, which exhibits striking sequence homology with members of the pancreatic polypeptide family, including neuropeptide tyrosine (NPY). The peptide is localized to enteroglucagon containing (L/EG) and pancreatic (A) cells in many mammalian and non-mammalian species. PYY gene expression is upregulated by various growth factors, including growth hormone and insulin-like growth factor and the physiological effects of PYY are mediated by G-protein (G alpha i2) coupled Y-type receptors (‘Y2 receptors of a PYY preferring subtype’). Various actions have been reported for PYY, including the inhibition of upper intestinal and exocrine pancreatic secretion, small intestinal water flux and as the mediator for the fat-induced ileal brake. Recently, the infusion of normal postprandial concentrations of PYY[3-36] into human volunteers has been shown to significantly decrease appetite and reduce food intake, possibly via Y2R in the arcuate nucleus. Immunohistochemical studies on mice have shown that PYY is the earliest detectable peptide in both pancreatic islets and colonic endocrine cells which suggest that PYY may be a useful marker for endocrine progenitor cells. This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded peptides may be associated with anorexia nervosa. [provided by RefSeq, Feb 2016] PYY1-36(human): Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2 CAS Number: 118997-30-1; Empirical Formula (Hill Notation): C194H295N55O57; Molecular Weight: 4309.75 Function: This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility. Subcellular Location: Secreted. Similarity: Belongs to the NPY family. SWISS: P10082 Gene ID: 5697 Database links: Entrez Gene: 5697 Human Entrez Gene: 217212 Mouse Omim: 600781 Human SwissProt: P10082 Human SwissProt: Q9EPS2 Mouse SwissProt: Q9TR93 Rabbit Unigene: 169249 Human Unigene: 46248 Mouse Unigene: 13173 Rat 酪酪肽簡介 酪酪肽PYY又稱腸道衍生激素酪酪肽，屬胰多肽家族成員，因它可使機體產(chǎn)生飽感、減少攝食和體重而為人們所知。隨著進(jìn)一步的深入研究，又發(fā)現(xiàn)其具有多種生物功能。 1、 PYY的蛋白結(jié)構(gòu):PYY與胰多肽（PP）和神經(jīng)肽Y（NPY）具有較高的序列同源性，故認(rèn)為屬胰多肽家族 。PYY是一種具有酰胺化羧基末端的肽類物質(zhì)，為直鏈多肽，其分子結(jié)構(gòu)為36個氨基酸縮合而成該肽的氨基和羧基末端的氨基酸殘基均為酪氨酸（Tyrosine,Tyr）。在循環(huán)系統(tǒng)中，PYY以PYY1-36 和PYY3-36兩種形式存在 。 2、 PYY的分泌及影響因素： PYY主要由結(jié)腸和直腸的L細(xì)胞以內(nèi)分泌和旁分泌兩種方式分泌； a.初期PYY是由結(jié)腸的內(nèi)分泌細(xì)胞所產(chǎn)生，該激素與胃腸道的形成和發(fā)育過程具有一定的關(guān)系。 b.PYY也可以由胃和胰腺的內(nèi)分泌細(xì)胞所分泌，同時在中樞神經(jīng)系統(tǒng)（下丘腦、腦干、髓質(zhì)、腦橋和脊髓）和末梢神經(jīng)系統(tǒng)的神經(jīng)元中存在。 c.在胰腺內(nèi)，PYY主要和胰高血糖素在胰島的α細(xì)胞內(nèi)共同表達(dá)。PYY在初期胰島細(xì)胞前體中的表達(dá)，說明它在胰腺的分化增殖和發(fā)育過程中起了重要的作用，從兩棲類動物的皮膚中也分離出一種PYY，稱為S-PYY。 3、PYY的作用： a.抑制胰島素的分泌：在體內(nèi)和體外實驗中PYY可以抑制胰島素的分泌。PYY是間接通過減少胰高血糖素的作用來影響胰島素的分泌。由于胰島素和PYY都是由胰島的β細(xì)胞分泌，因此，PYY可能是經(jīng)過旁分泌方式來調(diào)節(jié)胰島素的分泌，但胰高血糖素和PYY是否一起被分泌還需要進(jìn)一步的研究。 b.PYY還可以通過作用于中樞神經(jīng)系統(tǒng)來抑制胰島素的分泌。PYY可能與腦干內(nèi)的Y1和Y2受體結(jié)合來調(diào)節(jié)迷走神經(jīng)和影響攝食功能，這其中就包括調(diào)節(jié)胰島素的分泌。 c.抑制胃酸分泌：PYY 可以抑制由五肽胃泌素、膽堿能激動劑、刺激迷走神經(jīng)和組織胺所引起的胃酸分泌以及減少胃蛋白酶的含量，同時還可以增加血液中PYY的濃度。 d.PYY對攝食行為的調(diào)節(jié)： PYY的濃度在攝食前下降和攝食后增加，表明PYY是一個調(diào)節(jié)攝食的飽感信號。 |
