| 產(chǎn)品編號 | bs-1473R |
| 英文名稱 | Rabbit Anti-AKAP95 antibody |
| 中文名稱 | 蛋白激酶A錨定蛋白95抗體 |
| 別 名 | AKAP8; AKAP-8; AKAP-95; A-kinase Anchoring Protein 95; CCK 1; CCK1; CCL 28; Chemokine (C-C motif) ligand 28; MEC; Mucosae associated epithelial chemokine; SCYA28; Small inducible cytokine A28; AKP8L_HUMAN. |
| 研究領(lǐng)域 | 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 細(xì)胞周期蛋白 激酶和磷酸酶 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow,Chicken,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 71kDa |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human AKAP95: 401-550/646 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011] Function: Could play a role in constitutive transport element (CTE)-mediated gene expression. Does not seem to be implicated in the binding of regulatory subunit II of PKA. May be involved in nuclear envelope breakdown and chromatin condensation. May regulate the initiation phase of DNA replication when associated with TMPO-beta. Subunit: Interacts with PRPF40A. Binds to the C-terminal of RNA helicase A and to TMPO-beta. Interacts with RNF43. Subcellular Location: Nucleus matrix. Cytoplasm. Note=Colocalizes with PRPF40A in the nuclear matrix. Nuclear at steady state but shuttles between the nucleus and cytoplasm. Associated with the nuclear matrix. Tissue Specificity: Expressed in the brain cortex (at protein level). Post-translational modifications: Phosphorylated on serine or threonine residues possibly by PKA. Similarity: Belongs to the AKAP95 family. Contains 2 C2H2 AKAP95-type zinc fingers. SWISS: O43823 Gene ID: 10270 Database links: Entrez Gene: 10270 Human Entrez Gene: 56399 Mouse Omim: 604692 Human SwissProt: O43823 Human SwissProt: Q9DBR0 Mouse Unigene: 594496 Human 信號傳導(dǎo)（Signaling Intermediates） 蛋白激酶A錨定蛋白95參與細(xì)胞分裂染色體集縮的建立和集縮狀態(tài)的保持,參與基因表達(dá)調(diào)控、DNA復(fù)制以及維持mRNA的穩(wěn)定,參與胚胎發(fā)育、細(xì)胞凋亡及細(xì)胞周期調(diào)控等。 |
